Hey, Grey's Anatomy fans! Buckle up, because Season 22 is finally here, bringing back your favorite Grey Sloan doctors while introducing some fresh faces who are ready to shake things up. Plus, we're diving straight into the aftermath of that massive explosion!
TL;DR: Quick Takes for Busy Fans
- Trevor Jackson has been promoted to a series regular as the arrogant but brilliant intern, Wes Bryant, who's already causing romantic trouble.
- Two new recurring guest stars, Jade Pettyjohn (Dani) and Anita Kalathara (Kavita), are joining the Grey Sloan ranks.
- Season 22 premieres on Thursday, October 9, 2025, at 10 p.m. ET on ABC, promising to resolve last season's deadly cliffhanger.
The halls of Grey Sloan Memorial are about to get a little more crowded, and a lot more dramatic, with some exciting additions to the cast for Grey's Anatomy Season 22! If you thought things were intense last season, just wait.
First up, we've got a familiar face stepping into a bigger role. Trevor Jackson, who you might remember from grown-ish and American Crime, is officially a series regular! His character, Wes Bryant, made quite the impression in the last two episodes of Season 21. Described as handsome, intelligent, and a touch arrogant, Wes arrived in Seattle and immediately became a new medical intern at Grey Sloan. And, for those who caught the Season 21 finale, you know he already has a complicated history with intern Simone Griffith (Alexis Floyd) after their bar hookup. This is definitely going to spell trouble for Simone and Lucas (Niko Terho)!
But the new blood doesn't stop there. Season 22 is also welcoming two new recurring guest stars who are bound to make their mark:
- Jade Pettyjohn as Dani: You might recognize Jade from shows like Big Sky or Little Fires Everywhere. She's stepping into the role of Dani, another new medical intern. Our sources describe Dani as "overeager yet terrified with a good sense of humor," hoping to make her first day at the hospital one she'll definitely remember. We'll meet her right in the Season 22 premiere!
- Anita Kalathara as Kavita: Anita, known for her work in Doom Patrol, joins the team as Kavita. She'll play a "brilliant and attractive female plastic surgeon who is professional and straight to the point." We'll first see Kavita in Episode 2203, so get ready for some precise (and probably blunt) medical opinions.
Is Ellen Pompeo coming back to Grey's Anatomy? Get the latest scoop on Meredith Grey's future on the show possible Season 22 return and her new Hulu series. Read more on MoviesMoly!
Trevor Jackson on Joining the Iconic Grey's Anatomy Family
Becoming a series regular on a show as iconic as Grey's Anatomy is a huge deal, and Trevor Jackson is definitely feeling the excitement. He recently shared his feelings about the promotion, saying he was "freaking out" when he got the call. "I get to be a doctor on TV!" he exclaimed, expressing his pride in taking on the role.
Jackson also recognizes the significance of portraying a Black doctor on television, joining a long and impactful lineage of Black male medical professionals on screen. He told Essence, "Being a Black doctor on TV is something I take pride in. I don’t knock the athletes or rappers but it’s good to know that there’s more than one avenue for success for young Black men on TV. I feel like we’re portrayed one way a lot of the time so I love that I get to show something different."
As for what Wes Bryant will bring to the table? Jackson teased, "I came to shake some stuff up, and my character really just wants to be the best doctor he can be. And that may be good or bad for some people sometimes." Sounds like we're in for some classic Grey's drama!
"I came to shake some stuff up, and my character really just wants to be the best doctor he can be. And that may be good or bad for some people sometimes."
— Trevor Jackson on his character, Wes BryantAnd for a fun behind-the-scenes tidbit, Jackson admitted that the hardest part of the job wasn't learning complex medical jargon, but rather pronouncing a common hospital staple: "Saline!" He laughed, recalling takes where he kept saying "Celine" instead. It’s those little human moments that remind us even doctors on TV have their challenges!
Get the latest updates on The Voice Season 27 including schedule changes new coaches like Kelsea Ballerini and premiere episode highlights. Find out about blind auditions coach replay and contestant performances.
Who's Returning to Grey Sloan Memorial Hospital This Season?
Fear not, longtime fans! While we're excited for the new blood, many of your beloved Grey Sloan veterans and recent additions are back to face the new challenges that Season 22 will undoubtedly bring. Here's a rundown of the confirmed returning cast members:
- Ellen Pompeo as Meredith Grey
- Chandra Wilson as Miranda Bailey
- James Pickens Jr. as Richard Webber
- Kevin McKidd as Owen Hunt
- Kim Raver as Teddy Altman
- Camilla Luddington as Jo Wilson
- Caterina Scorsone as Amelia Shepherd
- Jason George as Ben Warren
- Chris Carmack as Atticus Lincoln (though his fate is teased!)
- Anthony Hill as Winston Ndugu
- Scott Speedman as Nick Marsh
- Alexis Floyd as Simone Griffith
- Harry Shum Jr. as Benson Kwan
- Adelaide Kane as Jules Millin
- Niko Terho as Lucas Adams
- Jake Borelli as Levi Schmitt
This mix of seasoned pros and the newer intern class means we'll continue to get the best of both worlds: deep, emotional storylines with characters we've grown to love for decades, and fresh, high-energy narratives from the residents finding their way in the intense world of Grey Sloan.
NCIS: Sydney Season 2 premiere delayed to February 7th 2025 but new episodes will still be available on streaming platforms the same week.
The Explosive Aftermath: Who Will Survive the Season 22 Premiere?
Let's not forget the terrifying cliffhanger from the Season 21 finale: a massive hospital explosion that left us all screaming at our screens! Trailers for Season 22 have made it abundantly clear that not everyone made it out, teasing "a main character death is looming." Get your tissues ready, because according to Jason George (who plays Ben Warren), "not everybody makes it out." He even hinted at "several deaths" in the premiere.
So, who's safe and who should we be worried about? We know for sure that Meredith Grey (Ellen Pompeo) and Ben Warren (Jason George) are safe, as they were outside the hospital when the blast occurred. But the fate of others hangs in the balance.
The trailer shows Dr. Atticus "Link" Lincoln (Chris Carmack) is listed as "missing," which could be a classic Grey's red herring to heighten the suspense. However, the conspicuous absence of Dr. Monica Beltran (Natalie Morales) has raised some eyebrows. Could her fate be why Dr. Amelia Shepherd (Caterina Scorsone) looks so distraught in the promos?
The Season 22 premiere, titled "Only the Strong Survive," will pick up right after the explosion. The official synopsis states: "After the catastrophic hospital explosion, Grey Sloan’s staff scrambles to save not only their patients’ lives, but also their own. Confronted with impossible surgical decisions and emotional trauma, they fight to preserve life amid the devastation." It sounds like a heart-wrenching start to the season, so prepare yourselves for an emotional rollercoaster.
The Challenge All Stars Season 5 Rivals is set to premiere on MTV. Discover the cast pairs theme premiere date streaming options and what to expect from this exciting season.
Where and When to Catch All the Grey's Anatomy Drama
Mark your calendars, set your alarms, and clear your schedules, because Grey's Anatomy Season 22 premieres on Thursday, October 9, 2025, at 10 p.m. ET/PT on ABC. It will air right after the season premieres of 9-1-1 and 9-1-1: Nashville, making for a packed night of medical and emergency drama!
If you're a cord-cutter, don't worry, you won't miss out. New episodes will be available to stream the very next day on Hulu. And if you're looking to watch live without cable, you have a few options with free trials:
- fuboTV: Offers a 5-day free trial.
- DirecTV Stream: Also provides a 5-day free trial.
- Hulu + Live TV: Features a 3-day free trial.
So, whether you're gathering around the TV on Thursday night or catching up the next day, you have plenty of ways to stay updated on all the Grey Sloan action.
9-1-1 Season 8 is back with a crazy midseason premiere! Maddie gets kidnapped and the kidnapper reveal is wild. Plus Eddie's Texas move and what to expect next episode. Get all the details on MoviesMoly.
Looking Ahead: What to Expect from Season 22 of Grey's
With showrunner Meg Marinis still at the helm and executive producers like Shonda Rhimes and Debbie Allen ensuring the show's signature blend of surgical intensity and human storytelling, Season 22 is poised to deliver everything fans love. The season is expected to have around 18 episodes, following the pattern of previous seasons.
Traditionally, Grey's Anatomy takes a winter break, usually around November, and then resumes in the spring. So, expect a mid-season finale before the holidays and a thrilling return sometime in March. The season finale will likely hit screens in late May or early June, wrapping up what promises to be another unforgettable year at Grey Sloan Memorial.
Get ready for impossible surgical decisions, tangled love triangles, and the raw emotional turmoil that only Grey's Anatomy can deliver. This season sounds like it's going to be absolutely wild!
Frequently Asked Questions About Grey's Anatomy Season 22
- Deadline: 'Grey's Anatomy' Ups Trevor Jackson To Series Regular, Adds Jade Pettyjohn & Anita Kalathara As Recurring For Season 22
- Essence: Trevor Jackson Is The Newest Doctor On Grey's Anatomy Season 22
- Syracuse.com: ‘Grey’s Anatomy’ Season 22 premiere: How to watch live stream for free without cable
- PopCulture.com: 'Grey's Anatomy' Ups Trevor Jackson To Series Regular, Adds Jade Pettyjohn & Anita Kalathara As Recurring For Season 22
- Just Jared: 'Grey's Anatomy' Season 22 Cast Changes: 17 Actors Confirmed to Return Thanks to ABC Promo Photos, 2 New Stars Added
- NBC10.com: Trevor Jackson says he will 'shake some stuff up' as Grey’s Anatomy’s newest doctor